Э-э-э, дорогой Hard, да Вы пожалуй или читать не можете, даже на русском, или пишете одно, подразумевая другое.
Миноксидил эффективен для лечения андрогенетической алопеции обоих полов, а не "мужской генетически обусловленной алопецией". Что Вы называете под этим именем мне не известно, может это?
Clin Exp Dermatol. 2002 Jul;27(5):405-9.
Epidemiology and genetics of alopecia areata.
McDonagh AJ, Tazi-Ahnini R.
Department of Dermatology and Division of Genomic Medicine, Royal Hallamshire Hospital, University of Sheffield, UK.
The frequency of alopecia areata and observed patterns of heritability are in keeping with a polygenic inheritance model but the genetics of alopecia areata is still poorly understood. The role of environmental factors in triggering disease initiation or exacerbation remains almost entirely speculative. Using the candidate gene approach, three susceptibility/severity factors have been identified. HLA alleles were the first to show a strong association with alopecia areata and some DQB and DR alleles have been demonstrated to confer a high risk for disease by both case-control and family-based studies. Interleukin (IL)-1 cluster genes, mainly the IL-1 receptor antagonist, show a strong association with disease severity in alopecia areata and a number of other autoimmune and inflammatory diseases. Finally, the association of alopecia areata with Down's syndrome, the high frequency of alopecia areata in autoimmune polyglandular syndrome type I due to mutations of the autoimmune regulator (AIRE) gene on chromosome 21q22.3 and the finding of association with MX1, another gene in the Down's syndrome region of chromosome 21 indicate this area of the genome as a promising target for future-family based investigations. The role of individual genes of the MHC, IL-1 cluster or chromosome 21q22.3 is difficult to establish and further genetic and functional investigations are needed to confirm their involvement in the pathogenesis of alopecia areata.
Или опять что-то на основании Ваших наблюдений?
По алопеции ареата нет однозначного мнения использования миноксидила, неплохой опыт по гормонам, антралину, есть публикации по пользованию иквимода, такролимуса, гипотезы по талидомиду.
Вообще, раскройте секреты как заболевания (лучше на английском), так и таинственную инструкцию от загадочного Kirklanda, который не значится даже в списках фармакокомпаний.
Кое-что по генетике андрогенетической алопеции здесь: ...it is not clear whether AGA is genetically homogeneous; some authorities suggest that female pattern hair loss is not the female counterpart of male AGA, and not androgen-dependent (Orme et al., 1999). The genes for type 1 and type 2 5-reductase have been shown not to be associated with the inheritance of AGA ( Ellis et al., 1998). Polymorphism of the AR gene is associated with male pattern baldness ( Ellis et al., 2001), however, the AR gene is located on the X chromosome and does not explain the relatively strong concordance of the degree of baldness in fathers and sons. No specific gene has been identified so far, though single gene mutations, such as abnormality of the AR, might be necessary, but not sufficient for the phenotype ( Ellis et al., 2001). We probably deal with a polygenic inheritance, dependent on a combination of mutations, e.g. in or around the AR gene affecting the expression of the AR, and other genes controlling androgen levels. Interactions between such genes might account for the tissue-specific and developmental stage-specific expression of the AR that is necessary to explain the characteristic anatomic and temporal patterns of AGA. Other genes relevant to androgens, including those on the Y chromosome might also be examined.
Просьба еще раз разобраться с номенклатурой алопеции и почитать уже опубликованные материалы по ведению каждой из них, прежде, чем ставить что-либо под сомнение.
например универсально по облысению мужчин:
South Med J. 2000 Jul;93(7):657-62.
Male pattern baldness.
Hogan DJ, Chamberlain M.
Section of Dermatology, Louisiana State University School of Medicine, Shreveport 71130-3932, USA.
BACKGROUND: Male pattern baldness, or androgenetic alopecia (AGA) in men, occurs with varying severity and age of onset. Two new treatments widely available as alternatives to 2% minoxidil are 1 mg finasteride and topical 5% minoxidil. Finasteride is a 5 alpha-reductase inhibitor available by prescription only; 5% minoxidil is available over the counter. METHODS: We searched MEDLINE to identify all articles on AGA and its pharmacologic therapies. RESULTS: We found limited information on AGA in peer review medical journals. Associated diseases include psychologic disorders and coronary heart disease. Hair growth is unpredictable and limited for all pharmacologic therapies, with the vast majority of treatment studies being industry sponsored. CONCLUSION: AGA is not easy to treat. Finasteride and 5% minoxidil offer new therapeutic options to the balding man. Treatment options may improve as new drugs are further investigated.
Естественно, если миноксидил или финанстерид тотально помогал всем, то не нужно было бы писать вышеуказанное, а также пересаживать пациентам волосы или носить камуфляжи. Но пренебрегать рекомендациям по лечению или ведению таких пациентов, кажется, не то, что неэтичным, а просто безграмотным (камень в огород Кирклэнду, если в его инструкции написано указанное Вами).
Drugs. 2001;61(1):53-69.
Treatments for androgenetic alopecia and alopecia areata: current options and future prospects.
Meidan VM, Touitou E.
Department of Pharmaceutics, School of Pharmacy, Faculty of Medicine, The Hebrew University, Jerusalem, Israel.
Androgenetic alopecia and alopecia areata are common disorders of the hair follicle which may heavily influence self esteem and self image. Androgenetic alopecia is caused by the heightened sensitivity of scalp follicles to dihydro- testosterone whereas alopecia areata is induced by an autoimmune reaction. Current drug treatment approaches include the use of regrowth stimulators such as topical minoxidil and oral finasteride for androgenetic alopecia, as well as topical minoxidil, dithranol (anthralin), corticosteroids, contact sensitisers, and psoralen plus ultraviolet A irradiation (PUVA) therapy for alopecia areata. Combination regimens are also proposed. However, extreme cases of either type of alopecia do not generally respond well to these existing treatments. For this reason, new therapeutic strategies are directed towards both improving the targeting of existing agents, as well as the development of novel hypertrichotic modalities.
