Уважаемый Hematolog!
Может Вы тоже в чем-то правы: лучше пожалуй скажут только эксперты:
так о питании (витаминах в пище) и предотвращении опухолей в популяции излагает
Donaldson MS. Nutrition and cancer: A review of the evidence for an anti-cancer diet.Nutr J. 2004 Oct 20;3(1):19.
http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=15496224
Другой пример: при лечении новым "антифолатным" метаболитом Pemetrexed (ALIMTA), для снижения его токсичности на КМ и эпителий кишечника назначается кобаламин и фолиевая за неделю до его введения и на весь курс терапии: подробнее напр.
http://clincancerres.aacrjournals.org/cgi/content/full/10/12/4276S
О не совсем полезности частичной коррекции кобаламинного дефицита при его обнаружении повествует отрывок:
Neurologic Effects of Deficiency
In the past, neurologic complications were thought to occur at a later stage of vitamin B12 deficiency than hematologic changes, but recent reports indicate that neurologic changes can occur in the absence of any hematologic abnormalities.
Neurologic complications are found in 75%90% of individuals with clinically apparent vitamin B12 deficiency. In 25%-33% of patients with neurologic symptoms, the only clinical manifestation is neuropathy. The occurrence of neurologic findings due to vitamin B12 deficiency is inversely correlated with the degree of anemia, i.e. subjects with severe anemia show fewer or no neurologic manifestations and vice versa.
Healton et al. showed that patients usually develop neurologic symptoms in their seventh decade or later. Only 20% of patients with neurologic symptoms become symptomatic before age 50.
Cobalamin deficiency of the nervous system is a progressive disorder, which is manifested by abnormalities of the spinal cord, peripheral nerves, optic nerves, and cerebrum. In 33% of patients, there are sensory disturbances in the extremities (paresthesia or numbness) alone. Motor disturbances alone, especially gait ataxia, are present in 9% of cases. Cognitive impairment may occur, ranging from loss of concentration to memory loss, disorientation, and frank dementia, with or without mood changes. Anosmia, fecal and urinary incontinence, leg weakness, impaired manual dexterity, and impotence are less frequent symptoms. Rare symptoms are orthostatic lightheadedness, diminished taste, paranoid psychosis, and diminished visual acuity.
Myelopathy alone is present in 12% of cases, whereas combined neuropathy and myelopathy are present in 41% of cases. Bilateral cerebral dysfunction is found in 8.1% of patients with neurologic symptoms, which suggests involvement of cortical neurons or the adjacent white matter. Cognitive syndromes, such as dementia, hallucinations, frank psychosis, paranoia, depression, violent behavior, and changes in personality are not frequent, but vitamin B12 deficiency should be considered as a possible cause of these symptoms. In 0.5% of cases, visual impairment was found, which might be related to optic atrophy and retrobulbar neuritis or pseudotumor cerebri. Depending on the duration of symptoms, neurologic complications of vitamin B12 deficiency may or may not be reversible following treatment (the longer the delay before treatment, the less likely recovery).
Из Baik HW, Russell RM. Vitamin B12 deficiency in the elderly. Annu Rev Nutr. 1999;19:357-77.
