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РЕМЕНС® (REMENS®)
Комплексный гомеопатический препарат
Состав: в 100 мл содержится Цимицифуга (Cimicifuga) D1 5 мл, Сангвинария канадская (Sanguinaria) D6 10 мл, Пилокарпус (Aristolochia) D6 10 мл, Каракатица, Сепия (Sepia) D12 10 мл, Яд змеи сурукуку (Lachesis) D12 10 мл, этиловый спирт 43 % по весу.
МЕНАЛЬГИН / MENALGIN®
Комплексный препарат природного происхождения, избавляет от болей при менструациях
Состав:
1 таблетка содержит:
Magnesium phosphoricum D2 - 25мг.
Chamomilla D2 - 25мг.
Colocynthis D3 - 25мг.
Potentilla anserina O - 100 мг (сухой остаток 1,7 мг).
Aesculus D1 - 25 мг.
Лактоза, магнезии стеарат, пшеничный крахмал.
Ацетаминофен acetaminophen - парацетамол.
Clin Ther. 2002 Sep;24(9):1384-400.
Comparison of the efficacy and safety of nonprescription doses of naproxen and naproxen sodium with ibuprofen, acetaminophen, and placebo in the treatment of primary dysmenorrhea: a pooled analysis of five studies.
Milsom I, Minic M, Dawood MY, Akin MD, Spann J, Niland NF, Squire RA.
Department of Obstetrics and Gynecology, Sahlgrenska University Hospital, Goteborg, Sweden.
BACKGROUND: Dysmenorrhea is the most common menstrual complaint in young women, with a prevalence as high as 90%. It is responsible for substantial repeated short-term absenteeism from school and work in young women. Effective treatments are available, including nonsteroidal anti-inflammatory drugs (NSAIDs). In many countries, a variety of NSAIDs have become available as over-the-counter (OTC) drugs. OBJECTIVE: The goal of this study was to compare the efficacy and safety of OTC doses of naproxen (400 mg) and naproxen/naproxen sodium (200/220 mg) with acetaminophen (1000 mg), ibuprofen (200 mg), and placebo in the treatment of primary dysmenorrhea. METHODS: A pooled analysis of 5 trials was performed. Efficacy was assessed by pain relief, relief of other dysmenorrheic symptoms, time to backup medication or remedication, and treatment preference. Tolerability was assessed by recording adverse events (AEs). RESULTS: A total of 443 women were enrolled in the combined studies. Naproxen 400 mg provided greater pain relief than acetaminophen and placebo within 30 minutes of administration (P < 0.01 and P < 0.05, respectively). Furthermore, naproxen 400 mg and 200 mg provided greater pain relief than both acetaminophen (P < 0.01 and P < 0.05, respectively) and ibuprofen (P < 0.001 and P < 0.01, respectively) at 6 hours after administration. Both doses of naproxen had higher scores than placebo for symptom relief and drug preference (all P < 0.001). The AEs and their frequency were similar among the treatment groups. No serious AEs were reported. CONCLUSION: When administered at OTC doses, naproxen was effective in the relief of pain and other symptoms of primary dysmenorrhea and had a good safety profile in the population studied.
Br J Obstet Gynaecol. 1998 Jul;105(7):780-9.
Efficacy of minor analgesics in primary dysmenorrhoea: a systematic review.
Zhang WY, Li Wan Po A.
Centre For Evidence-Based Pharmacotherapy, School of Pharmacy, University of Nottingham, UK.
OBJECTIVE: To quantify the efficacy and safety of naproxen, ibuprofen, mefenamic acid, aspirin and acetaminophen (paracetamol) in the treatment of primary dysmenorrhoea through a systemic overview of randomised controlled trials. METHODS: MEDLINE, EMBASE and the Science Citation Index were searched for randomised controlled trials. Efficacy was assessed by measurement of pain relief, requirement for rescue analgesics, restriction of daily life and absence from work or school. The rate ratios of side effects were used to assess safety. RESULTS: Fifty-six trials describing 55 comparisons of analgesics with placebo and 12 direct comparisons with other analgesics met our inclusion criteria. Women taking naproxen were over three times more likely to have at least moderate pain relief than those taking placebo. Ibuprofen, mefenamic acid and aspirin were also superior to placebo but acetaminophen was not. The requirement for rescue analgesics, restriction of daily life and absence from work or school were less frequent with naproxen and ibuprofen than placebo but not with aspirin or acetaminophen. Direct comparisons did not show any difference between naproxen and ibuprofen. Side effects occurred more frequently only with naproxen when compared with placebo. CONCLUSION: Naproxen, ibuprofen, mefenamic acid and aspirin are all effective in primary dysmenorrhoea. Ibuprofen appears to have the most favourable risk-benefit ratio. Acetaminophen appears to be less effective than nonsteroidal anti-inflammatory drugs, but there was only one trial meeting our inclusion criteria and further studies are required.
