...предлагаю начать обсуждение с вопроса (в третий раз уже): "Зачем лысому холестерин". Можно отдельную тему сделать
Уважаемый Антон Владимирович,
в целях развития Вами предлагаемой дискуссии (кроме тех материалов, которые уже размещал ранее), более ранний обзор эпид. наблюдений:
J Clin Epidemiol. 1990;43(11):1255-60.
Is baldness a risk factor for coronary artery disease? A review of the literature.
Herrera CR, Lynch C.
Division of General Internal Medicine, University of Texas Health Science Center, Houston 77030.
A literature search identified eight articles containing data on both baldness and coronary artery disease (CAD). Three of these articles described case-control studies that showed a positive relationship between baldness and CAD when controlling for CAD risk factors. Three other case-control studies showed no such relationship, but these did not control for CAD risk factors. The results of two cohort studies were inconclusive. Insufficient data were available from these studies to analyze possible relationships between baldness and CAD risk factors themselves. Overall, the data reviewed suggest that a small risk of CAD due to baldness may exist, but this risk is smaller than that of well-known CAD risk factors such as smoking and hypertension. Future research should emphasize proper control for age and CAD risk factors.
A так же разьяснялки от авторов этой работы:
Lotufo PA, Chae CU, Ajani UA, Hennekens CH, Manson JE.
Male pattern baldness and coronary heart disease: the Physicians' Health Study.
Arch Intern Med. 2000 Jan 24;160(2):165-71.
In our discussion of possible mechanisms that may explain the observed association between male pattern baldness and the increased risk of CHD, we mentioned elevated androgen levels. As we cited in our article, there is a consistent body of evidence from both laboratory and human studies implicating elevated androgen levels in several aspects of atherogenesis. While testosterone is the most abundant androgen in the plasma of men, dihydrotestosterone may also be involved in these pathways. For example, dihydrotestosterone, which has been implicated in male pattern baldness, has far greater mitogenic activity than testosterone in vascular smooth muscle cells isolated from rat aorta.
Several studies have documented that the administration of high doses of exogenous androgens as well as use of anabolic steroids resulted in dyslipidemia, elevated blood pressure, and an enhanced tendency for thrombosis. The results of our study suggested that the misuse of androgens and androgen precursors may have more long-term harmful effects than previously recognized.
After our article was submitted for publication, Signorello et al published an intriguing cross-sectional study among men older than 65 years that corroborated an association between vertex baldness and higher testosterone levels and described a positive association between vertex baldness and insulin-like growth factor 1. Among individuals with essential hypertension, elevated levels of insulin-like growth factor 1 have been associated with left ventricular hypertrophy, a powerful independent predictor of cardiovascular morbidity and mortality. Thus, it is possible that hormones other than androgens may explain the association between vertex baldness and CHD.
We also discussed non–androgen-related mechanisms in our article. Genetic factors are a possibility, as suggested by a similar pattern of inheritance for male pattern baldness and polycystic ovary syndrome, a common familial condition in women characterized by elevated androgen levels. Women with this syndrome (whose brothers have an increased prevalence of male pattern baldness) are likely to have an adverse cardiovascular risk profile and an increased risk of subclinical atherosclerosis.
More research is clearly needed to elucidate the apparent link between male pattern baldness and the risk of cardiovascular disease. Regardless of the mechanisms involved, male pattern baldness appears to serve as a marker for the increased risk of cardiovascular disease. Men with this condition may benefit from vigilant attention to prevention efforts directed toward known modifiable risk factors for CHD.
Arch Intern Med. 2000;160:2064-2065.
то есть американские предположения простые - пришел лысый на прием - подозревать как потенциального носителя ИБС, а если еще АД и холестерин повышены, то лечить активно и без всяких наблюдений.
Ох уж, этим лысым (в отличие от рыжих) и в этом не повезло.
) всего лишь 25 врачей, а всего сотрудников (с медсестрами и санитарками) - около 100 человек.
), которые так или иначе сталкиваются с проблемами алопеции.
